Application of Microbial Fermentation in the Development and Utilization of Chinese Herbal Medicine

In the development and utilization of Chinese herbal medicine resources, microbial fermentation has become an effective method. After the Chinese herbal medicine is microbial enzyme system, the fiber and wood parts become loose, the active ingredients are effectively released, and even new active substances are produced, which greatly improves and improves the efficacy. After microbial fermentation, the active macromolecular substances in Chinese herbal medicine are converted into small molecular substances that can be directly absorbed by the animal intestines, which are fully metabolized in the animal body to avoid drug residues. In addition, the prebiotics produced by Chinese herbal medicine after fermentation can promote the reproduction of microorganisms, and microorganisms can also promote the absorption and utilization of Chinese herbal medicine, the two complement each other and synergistically.

Traditional Chinese herbal medicine fermentation is the natural fermentation of microorganisms in the air. The process is controlled by subjective experience, so it is difficult to guarantee the stability of product quality. The products fermented by traditional Chinese herbal medicine are mostly pieces of Liushenqu and red yeast, which is not conducive to the marketization of Chinese herbal medicine. Modern Chinese herbal medicine fermentation is no longer limited to traditional Chinese herbal medicine fermentation, but Chinese herbal medicine fermentation is combined with bioengineering and microbiology, and modern biotechnology is used in the whole fermentation process to control the fermentation parameters (strain status, temperature and humidity, ventilation Situation and pH, etc.), greatly improving the quality of modern fermented Chinese herbal medicine.

The essence of microbial transformation is a chemical reaction that uses enzymes generated during the growth and metabolism of microorganisms to modify the structure of a specific substrate. It has the advantages of strong regional and stereoselectivity, mild reaction conditions, simple operation, low cost, and low pollution. The enzymes produced by microorganisms in the process of fermenting Chinese herbal medicine can digest plant cell walls, greatly release active substances, degrade toxic substances, and produce new biologically active substances, thereby biologically transforming the active ingredients of Chinese herbal medicines The substance is converted into a small molecule substance that can be directly absorbed by the intestine of the animal, making the Chinese herbal medicine a new drug with rapid absorption and quantitative curative effect.